Your spyware app removed a program (or registry key) that was needed (by the spyware most likely). Try a search for THotKey and see what turns up.
Also, if you used a good spyware removal program, you should have a quaranteen cache of the stuff removed. If you do, restore it all, and see if that makes the message go away. Once you're back to square one, you can proceed with the spyware removal more methodically.
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