Re: x38 or p35 x38 with FSB of 1600 will support future quads. Also the PCI-Express slots are x16 and x16 while the p35 is x16 and x4. This means x38 will have better crossfire performance. If your getting the 3870X2 however, you can use either motherboards for and they will have the same performance Lastly x38 are suppose to overclock better as well. But a lot of people can overclock on p35 just as well as the x38
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