if you absolutely must use wine, there is the painless and easy way all bundled in an rpm called winetools, which will help you set up a windows executive enviorment...
http://www.von-thadden.de/Joachim/WineTools/
In all of my gaming experience, call of duty runs better than windows, but everything else is still lagging behind or missing some aspect that windows still has. For apps, photoshop is INCREDIBLY slow... and I've found errors in msoft office and the like.