Well if you want to lose 200-300 bucks then lose 1 of the hard drives (300GB is more than enough).
Downgrade your processor to the e6300 (I have both the e6300 and the e6600, granted the e6600 is better, but the e6300 is still amazingly fast, and when overclocked it can crush an AMD FX-62!).
And if you still need to save more after that, consider the x1900GT for your VGA (or a 7900GT) both are great cards and will see you through till Direct X 10 with ease.