They both work, I use the Xbox gamepad for most but prefur the mouse when in a firefight, I however have not tried using both while driving, having a wheelman while oanother shoots might be fun, Gotta fire up GTA and give it a try.
Dauntae
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Antec 200
Q9550

ASUS P5Q SE/R
CORSAIR 650TX
EVGA GTX285 (Love this card)

Kingston HyperX 6GB (2 x 2GB 2X1GB)4-4-4-12 I had it on hand so what the hey???
Keeps Me Happy
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