I am not a prophet. But i did install as a Desktop OS. Which is basically what you are asking correct? I installed it as if i would install XP or Vista and ran it as a desktop OS.
IT was tricky at first to get certain things working like aero and stuff like that. Had to find a special Anti-Virus for it since it is a server OS and you can run AVG or Avast free versions on it. I had to get NOD32 and install that. Which worked jsut fine.
But other than that every app that i run on XP/Vista installed and ran easily.