Vista is just like XP. The thing with Business edition is that you dont ahve the Media Center part like Home PRemium does. I do have a serial for that as well. I forgot about that one hiding away.
But Using Vista is just like using XP. You have to make sure that you have the current versions of your apps and that is about it. Some apps dont have a Vista compatible version. Like some video conversion apps. While others you can run in XP SP2 compatibility mode and they work fine.
Hit me up on PM Totter and let me know what apps you are looking to run. I will let you know if i see any issues with them or if i know of a solution to the apps that wont work.