I have little-to-no-faith in any anti-virus, but one I was test-running, NOD32:
Antivirus Software - Eliminate Spyware and Adware with NOD32 Antivirus from ESET
The interface is nice and isn't bloated like most (Norton, PCcillin, AVG, ...all I've seen previously). Although I have not seen anything special beyond that, but if it's comparable "protection"-wise to the others, which of course they claim, I'd give it a shot!