In the little I've used vista I've been impressed, in everything I've read about vista I've been impressed, with the exception of my soundcard I spent $100 being worthless in many programs and thats the only thing I could knock against it.
The Creative ALchemy Project to make full use of your soundcard in EVERY program is excellent news, but it makes me mad that you have to pay for it, I feel they should support their customers.
Knowing this, I find it interesting to see how much people recommend spending on soundcards for vista, or bothering with them at all....